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Article

Amplicon deep sequencing improves Plasmodium falciparum genotyping in clinical trials of antimalarial drugs.

Scientific reports - 28 Nov 2019

Gruenberg Maria, Lerch Anita, Beck Hans-Peter, Felger Ingrid

Abstract excerpt

Clinical trials monitoring malaria drug resistance require genotyping of recurrent Plasmodium falciparum parasites to distinguish between treatment failure and new infection occurring during the trial follow up period. Because trial participants usually harbour multi-clonal P. falciparum infections, deep amplicon sequencing (AmpSeq) was employed to improve sensitivity and reliability of minority clone detection....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31780741
DOI: 10.1038/s41598-019-54203-0
PMCID: PMC6883076

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