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Article

Bacterial Replication Rate Modulation in Combination with Antimicrobial Therapy: Turning the Microbe against Itself.

Antimicrobial agents and chemotherapy - 1 Jan 2017

Ambrose Paul G, VanScoy Brian, Conde Haley, McCauley Jennifer, Rubino Christopher M, Bhavnani Sujata M

Abstract excerpt

A major clinical challenge for treating infectious diseases is the duration of antimicrobial therapy required to eradicate the pathogen. We hypothesized that modulation of the bacterial replication rate in the context of an antimicrobial exposure is coupled with the rate and extent of bactericidal effects. Herein we describe results from in vitro infection model (one compartment, 24-h model; hollow fiber, 10-day...

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Identifiers

PMID: 27821440
DOI: 10.1128/AAC.01605-16
PMCID: PMC5192140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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