Article
Optimization of a Meropenem-Tobramycin Combination Dosage Regimen against Hypermutable and Nonhypermutable Pseudomonas aeruginosa via Mechanism-Based Modeling and the Hollow-Fiber Infection Model.
Antimicrobial agents and chemotherapy - 1 Apr 2018
Landersdorfer Cornelia B, Rees Vanessa E, Yadav Rajbharan, Rogers Kate E, Kim Tae Hwan, Bergen Phillip J, Cheah Soon-Ee, Boyce John D, Peleg Anton Y, Oliver Antonio, Shin Beom Soo, Nation Roger L, Bulitta Jürgen B
Abstract excerpt
Hypermutable Pseudomonas aeruginosa strains are prevalent in patients with cystic fibrosis and rapidly become resistant to antibiotic monotherapies. Combination dosage regimens have not been optimized against such strains using mechanism-based modeling (MBM) and the hollow-fiber infection model (HFIM). The PAO1 wild-type strain and its isogenic hypermutable PAOΔmutS strain (MICmeropenem of 1.0 mg/liter and...
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