Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Time-dependent pharmacodynamics of amikacin on Mycobacterium abscessus growth and resistance emergence

18 Jan 2024

Abstract excerpt

ABSTRACT Mycobacterium abscessus pulmonary disease is increasing in prevalence globally, particularly for individuals with cystic fibrosis. These infections are challenging to treat due to a high rate of resistance. Amikacin is critical to treatment, but the development of toxicity, amikacin resistance, and treatment failure are significant challenges. Amikacin has been characterized previously as peak-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Infectious Diseases and Mycology
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38236037
DOI: 10.1128/spectrum.03222-23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Time-dependent pharmacodynamics of amikacin on Mycobacterium abscessus growth and resistance emergencePMID 38236037Read ↗

Antibiotic dose-response curves can measure antibiotic activity against <i>Mycobacterium abscessus</i> and <i>Mycobacterium peregrinum</i>Semantic proximity Read ↗

Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection ModelSemantic proximity Read ↗

Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to HumansSemantic proximity Read ↗

Bacterial Replication Rate Modulation in Combination with Antimicrobial Therapy: Turning the Microbe against Itself.Semantic proximity Read ↗

Mathematical modeling links benefits of short and long antibiotic treatment to details of infectionSemantic proximity Read ↗

Suggested Dosing of Select Beta-lactam Agents for the Treatment of Antimicrobial-Resistant Gram-Negative Infections in ChildrenSemantic proximity Read ↗

Unraveling antibiotic resistance mechanisms in Mycobacterium abscessus: the potential role of efflux pumpsSemantic proximity Read ↗

<i>In Vitro</i> Activity of Amikacin against Isolates of Mycobacterium avium Complex with Proposed MIC Breakpoints and Finding of a 16S rRNA Gene Mutation in Treated IsolatesSemantic proximity Read ↗

Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa: In Vivo and In Vitro EvidenceSemantic proximity Read ↗

Modelling biphasic killing of fluoroquinolones: guiding optimal dosing regimen design.Semantic proximity Read ↗

Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Optimization of a Meropenem-Tobramycin Combination Dosage Regimen against Hypermutable and Nonhypermutable Pseudomonas aeruginosa via Mechanism-Based Modeling and the Hollow-Fiber Infection Model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.