Article

Simultaneous in vitro simulation of multiple antimicrobial agents with different elimination half-lives in a pre-clinical infection model

2020-12-22

Abstract excerpt

Combination therapy for treatment of multi-drug resistant bacterial infections is becoming increasingly common. In vitro testing of drug combinations under realistic pharmacokinetic conditions is needed before a corresponding combination is eventually put into clinical use. The current standard for in vitro simulation of the pharmacokinetics of two drugs with distinct elimination half-lives cannot be extended for...

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Literature Corpus work: 5d8d3e20-69d7-582a-817c-303ca5b823ed
DOI: 10.1101/2020.12.21.405464

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