Article

Unraveling Resistance and Thresholds in Phage Therapy Using <i>Staphylococcus aureus</i> In Vitro Models

2025-04-29

Abstract excerpt

<h4>Background</h4> Phage therapy is a promising approach against multidrug-resistant Staphylococcus aureus , but its clinical development is limited by gaps in pharmacokinetic/pharmacodynamic (PK/PD) understanding, especially concerning phage self-replication and resistance dynamics. <h4>Methods</h4> We combined in vitro time-kill assays with PK/PD modeling to study three anti-staphylococcal phages (V1SA019,...

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Literature Corpus work: 890eb0bc-dbea-5901-a2fe-3c9f032b2dec
DOI: 10.1101/2025.04.25.650594

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