Article
The combination of meropenem and levofloxacin is synergistic with respect to both Pseudomonas aeruginosa kill rate and resistance suppression.
Antimicrobial agents and chemotherapy - 1 Jun 2010
Louie Arnold, Grasso Caroline, Bahniuk Nadzeya, Van Scoy Brian, Brown David L, Kulawy Robert, Drusano G L
Abstract excerpt
New approaches are needed for the treatment of Pseudomonas aeruginosa infections. All available single agents are suboptimal, especially for resistance suppression. Classical beta-lactam/aminoglycoside combinations are not used often enough at least in part because of concern for nephrotoxicity. We evaluated the combination of meropenem and levofloxacin against the P. aeruginosa PAO1 wild type and its isogenic...
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