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Iron promotes isocitrate dehydrogenase mutant glioma cell motility.

Free radical biology & medicine - 1 Jan 2025

Owusu Stephenson Boakye, Russell Emily, Ekanayake Akalanka B, Tivanski Alexei V, Petronek Michael S

Abstract excerpt

Enriched iron metabolic features such as high transferrin receptor (TfR) expression and high iron content are commonly observed in aggressive gliomas and can be associated with poor clinical responses. However, the underlying question of how iron contributes to tumor aggression remains elusive. Gliomas harboring isocitrate dehydrogenase (IDH) mutations account for a high percentage (>70 %) of recurrent tumors and...

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PMID: 39551451
DOI: 10.1016/j.freeradbiomed.2024.11.032

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