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Article

Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics

7 Nov 2016

Abstract excerpt

Celastrol, isolated from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f. (Thunder God's Vine), has been used to treat cancer, chronic inflammatory, autoimmune and other human diseases. However, to date, the protein targets and the mechanism of action of celastrol have remained elusive. In this study, we find that celastrol can react with protein thiols in a unique covalent and reversible...

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PMID: 27819370
DOI: 10.1039/c6mb00691d

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