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Mechanisms of action of triptolide against colorectal cancer: insights from proteomic and phosphoproteomic analyses

2 Apr 2022

Abstract excerpt

Triptolide is a potent anti-inflammatory agent that also possesses anticancer activity, including against colorectal cancer (CRC), one of the most frequent cancers around the world. In order to clarify how triptolide may be effective against CRC, we analyzed the proteome and phosphoproteome of CRC cell line HCT116 after incubation for 48 h with the drug (40 nM) or vehicle. Tandem mass tagging led to the...

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PMID: 35366242
DOI: 10.18632/aging.203992

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