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Article

The road to survival goes through PARG.

Cell cycle (Georgetown, Tex.) - 1 Mar 2005

Koh David W, Dawson Valina L, Dawson Ted M

Abstract excerpt

Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and...

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Source

Identifiers

PMID: 15725727
DOI: 10.4161/cc.4.3.1559

Genes

PARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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