Article
The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).
The Journal of biological chemistry - 14 Mar 2003
Schreiber Sylvia N, Knutti Darko, Brogli Kathrin, Uhlmann Thomas, Kralli Anastasia
Abstract excerpt
The estrogen-related receptor alpha (ERRalpha) is one of the first orphan nuclear receptors identified. Still, we know little about the mechanisms that regulate its expression and its activity. In this study, we show that the transcriptional coactivator PGC-1, which is implicated in the control of energy metabolism, regulates ERRalpha at two levels. First, PGC-1 induces the expression of ERRalpha. Consistent with...
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