Article
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Cell metabolism - 1 Dec 2006
Vianna Claudia R, Huntgeburth Michael, Coppari Roberto, Choi Cheol Soo, Lin Jiandie, Krauss Stefan, Barbatelli Giorgio, Tzameli Iphigenia, Kim Young-Bum, Cinti Saverio, Shulman Gerald I, Spiegelman Bruce M, Lowell Bradford B
Abstract excerpt
PGC-1beta is a transcriptional coactivator that potently stimulates mitochondrial biogenesis and respiration of cells. Here, we have generated mice lacking exons 3 to 4 of the Pgc-1beta gene (Pgc-1beta(E3,4-/E3,4-) mice). These mice express a mutant protein that has reduced coactivation activity on a subset of transcription factors, including ERRalpha, a major target of PGC-1beta in the induction of mitochondrial...
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