Article
Peptide serum markers in islet autoantibody-positive children.
Diabetologia - 1 Feb 2017
von Toerne Christine, Laimighofer Michael, Achenbach Peter, Beyerlein Andreas, de Las Heras Gala Tonia, Krumsiek Jan, Theis Fabian J, Ziegler Anette G, Hauck Stefanie M
Abstract excerpt
AIMS/HYPOTHESIS: We sought to identify minimal sets of serum peptide signatures as markers for islet autoimmunity and predictors of progression rates to clinical type 1 diabetes in a case-control study. METHODS: A double cross-validation approach was applied to first prioritise peptides from a shotgun proteomic approach in 45 islet autoantibody-positive and -negative children from the BABYDIAB/BABYDIET birth...
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