Article
Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes.
Nature metabolism - 1 Sept 2026
Landman Joshua M, Highland Heather M, Perry Andrew S, Howard Annie G, Sheng Quanhu, Lorenz Anna, Palmer Alexandra B, Zhao Shilin, Zhu Wanying, Zhang Xinruo, Buchanan Victoria L, Frankel Elizabeth G, Roshani Rashedeh, Scartozzi Alyssa, Farber-Eger Eric H, Anwar Mohammad Y, Sprinkles Jessica K, Breidenbach Ash, Wang Ting-Chen, Ballard Christine A, Nayor Matthew, Tamaroff Jaclyn, Gutierrez Absalon, Petty Lauren E, Petty Alexander S, Lippi Benjamin, Fernandez-Rhodes Lindsay, Chen Hung-Hsin, Krishnan Mohanraj, Graff Mariaelisa, Meyer Katie A, Lee Miryoung, Young Kristin L, Wells Quinn, Tanriverdi Kahraman, Freedman Jane E, Gamazon Eric R, McCormick Joseph B, Fisher-Hoch Susan P, Gordon-Larsen Penny, Below Jennifer E, North Kari E, Shah Ravi V
Abstract excerpt
While the earliest pathological signs of cardiovascular-kidney-metabolic disease (CKMD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of children at high risk. With increasing childhood obesity, early, sensitive detection of CKMD risk is critical to timely intervention. We linked 25 CKMD phenotypes spanning liver, adipose, vascular and dysglycaemia traits to the...
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