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Article

Control of inflammation by stromal Hedgehog pathway activation restrains colitis.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2016

Lee John J, Rothenberg Michael E, Seeley E Scott, Zimdahl Bryan, Kawano Sally, Lu Wan-Jin, Shin Kunyoo, Sakata-Kato Tomoyo, Chen James K, Diehn Maximilian, Clarke Michael F, Beachy Philip A

Abstract excerpt

Inflammation disrupts tissue architecture and function, thereby contributing to the pathogenesis of diverse diseases; the signals that promote or restrict tissue inflammation thus represent potential targets for therapeutic intervention. Here, we report that genetic or pharmacologic Hedgehog pathway inhibition intensifies colon inflammation (colitis) in mice. Conversely, genetic augmentation of Hedgehog response...

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Identifiers

PMID: 27815529
DOI: 10.1073/pnas.1616447113
PMCID: PMC5127312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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