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Article

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.

The Journal of clinical investigation - 1 May 2011

Lerner Immanuel, Hermano Esther, Zcharia Eyal, Rodkin Dina, Bulvik Raanan, Doviner Victoria, Rubinstein Ariel M, Ishai-Michaeli Rivka, Atzmon Ruth, Sherman Yoav, Meirovitz Amichay, Peretz Tamar, Vlodavsky Israel, Elkin Michael

Abstract excerpt

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated with colon cancer. Expression of the enzyme heparanase is clearly linked to colon carcinoma progression, but its role in UC is unknown. Here we demonstrate for what we believe to be the first time the importance of heparanase in sustaining the immune-epithelial crosstalk underlying colitis-associated tumorigenesis. Using...

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Identifiers

PMID: 21490396
DOI: 10.1172/JCI43792
PMCID: PMC3083784

Genes

STAT3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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