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Article

Hedgehog Signaling: Networking to Nurture a Promalignant Tumor Microenvironment

21 Jul 2011

Abstract excerpt

In addition to its role in embryonic development, the Hedgehog pathway has been shown to be an active participant in cancer development, progression, and metastasis. Although this pathway is activated by autocrine signaling by Hedgehog ligands, it can also initiate paracrine signaling with cells in the microenvironment. This creates a network of Hedgehog signaling that determines the malignant behavior of the...

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PMID: 21775419
DOI: 10.1158/1541-7786.mcr-11-0175

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