Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions

16 Jan 2017

Abstract excerpt

Since its initial discovery in Drosophila , Hedgehog (HH) signaling has long been associated with foregut development. The mammalian genome expresses 3 HH ligands, with sonic hedgehog (SHH) levels highest in the mucosa of the embryonic foregut. More recently, interest in the pathway has shifted to improving our understanding of its role in gastrointestinal cancers. The use of reporter mice proved instrumental in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Hedgehog Signaling Pathway Studies
Share to Tumors and Oncological Cases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28275687
DOI: 10.1016/j.jcmgh.2017.01.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor LesionsPMID 28275687Read ↗

From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseasesSemantic proximity Read ↗

Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia.Semantic proximity Read ↗

Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathwaysSemantic proximity Read ↗

Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer.Semantic proximity Read ↗

Hedgehog signaling pathway and gastric cancerSemantic proximity Read ↗

Suppression of growth and migration by blocking the hedgehog signaling pathway in gastric cancer cellsSemantic proximity Read ↗

Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein SignalingSemantic proximity Read ↗

Intracellular Hedgehog signaling controls Th17 polarization and pathogenicitySemantic proximity Read ↗

Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progressionSemantic proximity Read ↗

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.Semantic proximity Read ↗

Stem Cells, Helicobacter pylori, and Mutational Landscape: Utility of Preclinical Models to Understand Carcinogenesis and to Direct Management of Gastric Cancer.Semantic proximity Read ↗

Hedgehog Signaling in Gastrointestinal Development and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.