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Article

Role of mitochondrial DNA in toxic responses to oxidative stress.

DNA repair - 3 Feb 2006

Van Houten Bennett, Woshner Victoria, Santos Janine H

Abstract excerpt

Mitochondria are at the crossroads of several crucial cellular activities including: adenosine triphosphate (ATP) generation via oxidative phosphorylation; the biosynthesis of heme, pyrimidines and steroids; calcium and iron homeostasis and programmed cell death (apoptosis). Mitochondria also produce considerable quantities of superoxide and hydrogen peroxide (H2O2) that in conjunction with its large iron stores...

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Identifiers

PMID: 15878696
DOI: 10.1016/j.dnarep.2005.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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