Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial DNA repair and aging.

Mutation research - 30 Nov 2002

Mandavilli Bhaskar S, Santos Janine H, Van Houten Bennett

Abstract excerpt

The mitochondrial electron transport chain plays an important role in energy production in aerobic organisms and is also a significant source of reactive oxygen species that damage DNA, RNA and proteins in the cell. Oxidative damage to the mitochondrial DNA is implicated in various degenerative diseases, cancer and aging. The importance of mitochondrial ROS in age-related degenerative diseases is further...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to Drosophila melanogaster
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Electron Transport

Share to Models, Animal

Share to Reactive Oxygen Species

Source

Identifiers

PMID: 12427535
DOI: 10.1016/s0027-5107(02)00220-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA repair and aging.PMID 12427535Read ↗

Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging.Semantic proximity Read ↗

Multiple Roles of Mitochondria in Aging ProcessesSemantic proximity Read ↗

Mitochondrial DNA Repair in Neurodegenerative Diseases and AgeingSemantic proximity Read ↗

Role of mitochondrial DNA in toxic responses to oxidative stress.Semantic proximity Read ↗

Mitochondrial DNA repair in aging and disease.Semantic proximity Read ↗

Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging.Semantic proximity Read ↗

Mitochondrial DNA Damage and DiseasesSemantic proximity Read ↗

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases.Semantic proximity Read ↗

Mitochondria and AgeingSemantic proximity Read ↗

Mitochondrial DNA alterations and reduced mitochondrial function in aging.Semantic proximity Read ↗

Mitochondria and aging.Semantic proximity Read ↗

The role of mitochondrial DNA mutations and free radicals in disease and ageing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.