Article
An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome.
Annals of internal medicine - 6 Apr 1999
Straus S E, Sneller M, Lenardo M J, Puck J M, Strober W
Abstract excerpt
The autoimmune lymphoproliferative syndrome (ALPS) affords novel insights into the mechanisms that regulate lymphocyte homeostasis and underlie the development of autoimmunity. This syndrome arises early in childhood in persons who inherit mutations in genes that mediate apoptosis, or programmed cell death. The timely deletion of lymphocytes is a way to prevent their accumulation and the persistence of cells that...
Topics
- Apoptosis
- Autoimmune Diseases
- Autoimmunity
- Female
- Humans
- Infant
- Lymphocytes
- Lymphoproliferative Disorders
- Mutation
- Syndrome