Article
Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish.
The Journal of experimental medicine - 14 Nov 2016
Moore John C, Tang Qin, Yordán Nora Torres, Moore Finola E, Garcia Elaine G, Lobbardi Riadh, Ramakrishnan Ashwin, Marvin Dieuwke L, Anselmo Anthony, Sadreyev Ruslan I, Langenau David M
Abstract excerpt
Cell transplantation into immunodeficient mice has revolutionized our understanding of regeneration, stem cell self-renewal, and cancer; yet models for direct imaging of engrafted cells has been limited. Here, we characterize zebrafish with mutations in recombination activating gene 2 (rag2), DNA-dependent protein kinase (prkdc), and janus kinase 3 (jak3). Histology, RNA sequencing, and single-cell...
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