Article
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants.
Nature immunology - 1 Dec 2003
Traver David, Paw Barry H, Poss Kenneth D, Penberthy W Todd, Lin Shuo, Zon Leonard I
Abstract excerpt
The zebrafish is firmly established as a genetic model for the study of vertebrate blood development. Here we have characterized the blood-forming system of adult zebrafish. Each major blood lineage can be isolated by flow cytometry, and with these lineal profiles, defects in zebrafish blood mutants can be quantified. We developed hematopoietic cell transplantation to study cell autonomy of mutant gene function...
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