Article
Optimized cell transplantation using adult rag2 mutant zebrafish.
Nature methods - 1 Aug 2014
Tang Qin, Abdelfattah Nouran S, Blackburn Jessica S, Moore John C, Martinez Sarah A, Moore Finola E, Lobbardi Riadh, Tenente Inês M, Ignatius Myron S, Berman Jason N, Liwski Robert S, Houvras Yariv, Langenau David M
Abstract excerpt
Cell transplantation into adult zebrafish has lagged behind mouse models owing to the lack of immunocompromised strains. Here we have created rag2(E450fs) mutant zebrafish that have reduced numbers of functional T and B cells but are viable and fecund. Mutant fish engraft muscle, blood stem cells and various cancers. rag2(E450fs) mutant zebrafish are the first immunocompromised zebrafish model that permits...
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