Article
Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Feb 2022
Islam Sadequl, Sun Yang, Gao Yuan, Nakamura Tomohisa, Noorani Arshad Ali, Li Tong, Wong Philip C, Kimura Noriyuki, Matsubara Etsuro, Kasuga Kensaku, Ikeuchi Takeshi, Tomita Taisuke, Zou Kun, Michikawa Makoto
Abstract excerpt
Alzheimer's disease (AD) is a debilitating dementia characterized by progressive memory loss and aggregation of amyloid-β (Aβ) protein into amyloid plaques in patient brains. Mutations in presenilin (PS) lead to abnormal generation of Aβ, which is the major cause of familial AD (FAD), and apolipoprotein E4 (ApoE4) is the major genetic risk factor for sporadic AD (SAD) onset. However, whether dysfunction of PS is...
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