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Article

MED12 exon 2 mutations in phyllodes tumors of the breast.

Cancer medicine - 1 Jul 2015

Nagasawa Satoi, Maeda Ichiro, Fukuda Takayo, Wu Wenwen, Hayami Ryosuke, Kojima Yasuyuki, Tsugawa Ko-Ichiro, Ohta Tomohiko

Abstract excerpt

Exon 2 of MED12, a subunit of the transcriptional mediator complex, has been frequently mutated in uterine leiomyomas and breast fibroadenomas; however, it has been rarely mutated in other tumors. Although the mutations were also found in uterine leiomyosarcomas, the frequency was significantly lower than in uterine leiomyomas. Here, we examined the MED12 mutation in phyllodes tumors, another biphasic tumor with...

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Source

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Identifiers

PMID: 25865354
DOI: 10.1002/cam4.462
PMCID: PMC4529349

Genes

MED12

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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MED12 exon 2 mutations in phyllodes tumors of the breast.PMID 25865354Read ↗

MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast.Semantic proximity Read ↗

Molecular pathology of phyllodes tumours of the breast-much more than MED12.Semantic proximity Read ↗

MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases.Semantic proximity Read ↗

Frequent MED12 mutations in phyllodes tumours of the breast.Semantic proximity Read ↗

MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways.Semantic proximity Read ↗

Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.Semantic proximity Read ↗

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.Semantic proximity Read ↗

Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors.Semantic proximity Read ↗

Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade.Semantic proximity Read ↗

Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing.Semantic proximity Read ↗

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.Semantic proximity Read ↗

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.Semantic proximity Read ↗

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