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Article

Constant-pH MD simulations of the protonation-triggered conformational switching in diphtheria toxin translocation domain.

Biophysical journal - 17 Dec 2024

Oliveira Nuno F B, Ladokhin Alexey S, Machuqueiro Miguel

Abstract excerpt

Protonation of key residues in the diphtheria toxin translocation (T)-domain triggered by endosomal acidification is critical for inducing a series of conformational transitions critical for the cellular entry of the toxin. Previous experiments revealed the importance of histidine residues in modulating pH-dependent transitions. They suggested the presence of a "safety latch" preventing premature refolding of the...

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Identifiers

PMID: 39215463
DOI: 10.1016/j.bpj.2024.08.023
PMCID: PMC11700360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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