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Article

Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain.

Toxins - 7 Nov 2020

Rodnin Mykola V, Kashipathy Maithri M, Kyrychenko Alexander, Battaile Kevin P, Lovell Scott, Ladokhin Alexey S

Abstract excerpt

Diphtheria toxin, an exotoxin secreted by Corynebacterium that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes, resulting in the refolding and membrane insertion of the translocation (T-)domain and ultimately leading to the translocation of the catalytic domain into the...

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Identifiers

PMID: 33171806
DOI: 10.3390/toxins12110704
PMCID: PMC7695028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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