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Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease.

Scientific reports - 2 Nov 2016

Chen Yen-Ching, Hsiao Chi-Jung, Jung Chien-Cheng, Hu Hui-Han, Chen Jen-Hau, Lee Wen-Chung, Chiou Jeng-Min, Chen Ta-Fu, Sun Yu, Wen Li-Li, Yip Ping-Keung, Chu Yi-Min, Chen Chien-Jen, Yang Hwai-I

Abstract excerpt

Previous genome-wide association studies using P-values to select single nucleotide polymorphisms (SNPs) have suffered from high false-positive and false-negative results. This case-control study recruited 713 late-onset Alzheimer's disease (LOAD) cases and controls aged ≥65 from three teaching hospitals in northern Taiwan from 2007 to 2010. Performance metrics were used to select SNPs in stage 1, which were then...

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Identifiers

PMID: 27805002
DOI: 10.1038/srep36155
PMCID: PMC5090242

Genes

APOC1
APOE
CPXM2

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