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Article

Dual role of the integrated stress response in medulloblastoma tumorigenesis.

Oncotarget - 27 Sept 2016

Stone Sarrabeth, Ho Yeung, Li Xiting, Jamison Stephanie, Harding Heather P, Ron David, Lin Wensheng

Abstract excerpt

In response to endoplasmic reticulum (ER) stress, activation of pancreatic ER kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating translation initiation factor 2α (eIF2α). Phosphorylated eIF2α is quickly dephosphorylated by the protein phosphatase 1 and growth arrest and DNA damage 34 (GADD34) complex. Data indicate that the ISR can either promote or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27802424
DOI: 10.18632/oncotarget.11873
PMCID: PMC5325430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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