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Article

PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma

22 Jun 2022

Abstract excerpt

Intratumor epigenetic heterogeneity is emerging as a key mechanism underlying tumor evolution and drug resistance. Epigenetic abnormalities frequently occur in medulloblastoma, the most common childhood malignant brain tumor. Medulloblastoma is classified into four subtypes including SHH medulloblastoma, which is characterized by elevated sonic hedgehog (SHH) signaling and a cerebellum granule neuron precursor...

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PMID: 35731926
DOI: 10.1158/0008-5472.can-21-4313

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