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Article

A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma.

Journal of neuroscience research - 1 Oct 2011

Lin Wensheng, Lin Yifeng, Li Jin, Harding Heather P, Ron David, Jamison Stephanie

Abstract excerpt

Endoplasmic reticulum (ER) stress activates pancreatic ER kinase (PERK), which coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating translation initiation factor 2α (eIF2α). There is evidence that the ISR is involved in tumor development. Recent studies also show that the ISR stimulates the expression of vascular endothelial growth factor A (VEGF-A), a master regulator...

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Source

Identifiers

PMID: 21688289
DOI: 10.1002/jnr.22693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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