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Article

Yeast cells reveal the misfolding and the cellular mislocalization of the human BRCA1 protein.

Journal of cell science - 1 Dec 2016

Thouvenot Pierre, Fourrière Lou, Dardillac Elodie, Ben Yamin Barbara, Lescure Aurianne, Lejour Vincent, Heiligenstein Xavier, Boulé Jean-Baptiste, Romao Maryse, Raposo-Benedetti Graça, Lopez Bernard S, Nicolas Alain, Millot Gaël A

Abstract excerpt

Understanding the effect of an ever-growing number of human variants detected by genome sequencing is a medical challenge. The yeast Saccharomyces cerevisiae model has held attention for its capacity to monitor the functional impact of missense mutations found in human genes, including the BRCA1 breast and ovarian cancer susceptibility gene. When expressed in yeast, the wild-type full-length BRCA1 protein forms a...

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Identifiers

PMID: 27802165
DOI: 10.1242/jcs.192880

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BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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