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Article

Stepwise Humanization of the Yeast TRAPP Core Enables Functional Analysis of TRAPP Variants.

Cells - 27 Aug 2026

Abboud Chelsea, Shokohi Rozmehr, Pape Olivia, Mehranfar Mahsa, Baple Emma L, Damseh Nadirah, Sacher Michael

Abstract excerpt

The Transport Protein Particle (TRAPP) complex is a highly conserved multi-subunit tethering complex that plays a critical role in membrane trafficking. Mutations in TRAPP complex subunits have been implicated in a growing spectrum of rare genetic disorders, yet the molecular mechanisms underlying variant pathogenicity often remain unclear. Here, we developed a humanized yeast platform to enable systematic...

Read the complete abstract on PubMed

Topics

Saccharomyces cerevisiae
Humans
Vesicular Transport Proteins
Mutation
Saccharomyces cerevisiae Proteins
Models, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Subunits

Source

Open in PubMed Open full text

Identifiers

PMID: 42738849
DOI: 10.3390/cells15171555
PMCID: PMC13564602

Genes

TRAPPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Stepwise Humanization of the Yeast TRAPP Core Enables Functional Analysis of TRAPP Variants.PMID 42738849Read ↗

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