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Article

Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily.

Biochemistry - 27 Sept 2005

Roodveldt Cintia, Tawfik Dan S

Abstract excerpt

The amidohydrolase superfamily comprises hundreds of hydrolytic enzymes of the (beta/alpha)8 barrel fold with mono- or binuclear active-site metal centers, and a diverse spectrum of substrates and reactions. Promiscuous activities, or cross-reactivities, between different members of the same superfamily may provide important hints regarding evolutionary and mechanistic relationships. We examined three members:...

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PMID: 16171387
DOI: 10.1021/bi051021e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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