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Article

Evolution of function in protein superfamilies, from a structural perspective.

Journal of molecular biology - 6 Apr 2001

Todd A E, Orengo C A, Thornton J M

Abstract excerpt

The recent growth in protein databases has revealed the functional diversity of many protein superfamilies. We have assessed the functional variation of homologous enzyme superfamilies containing two or more enzymes, as defined by the CATH protein structure classification, by way of the Enzyme Commission (EC) scheme. Combining sequence and structure information to identify relatives, the majority of superfamilies...

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Identifiers

PMID: 11286560
DOI: 10.1006/jmbi.2001.4513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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