Article
The Distal-Proximal Relationships Among the Human Moonlighting Proteins: Evolutionary hotspots and Darwinian checkpoints
2023-10-17
Abstract excerpt
Moonlighting proteins, known for their ability to perform multiple, often unrelated functions within a single polypeptide chain, challenge the traditional “one gene, one protein, one function” paradigm. As organisms evolved, their genomes remained relatively stable in size, but the introduction of post-translational modifications and sub-strategies like protein promiscuity and intrinsic disorder enabled multifunct...
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Identifiers and source
- Literature Corpus work
- 6f83e411-4849-57a3-a781-f3a19e3660d9
- DOI
- 10.1101/2023.10.12.562146