Article
Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis.
Epigenetics & chromatin - 1 Jan 2016
Pazienza Valerio, Panebianco Concetta, Rappa Francesca, Memoli Domenico, Borghesan Michela, Cannito Sara, Oji Asami, Mazza Giuseppe, Tamburrino Domenico, Fusai Giuseppe, Barone Rosario, Bolasco Giulia, Villarroya Francesc, Villarroya Joan, Hatsuzawa Kiyotaka, Cappello Francesco, Tarallo Roberta, Nakanishi Tomoko, Vinciguerra Manlio
Abstract excerpt
BACKGROUND: Obesity has tremendous impact on the health systems. Its epigenetic bases are unclear. MacroH2A1 is a variant of histone H2A, present in two alternatively exon-spliced isoforms macroH2A1.1 and macroH2A1.2, regulating cell plasticity and proliferation, during pluripotency and tumorigenesis. Their role in adipose tissue plasticity is unknown. RESULTS: Here, we show evidence that macroH2A1.1 protein...
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