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Article

Developmental changes in histone macroH2A1-mediated gene regulation.

Molecular and cellular biology - 1 Apr 2007

Changolkar Lakshmi N, Costanzi Carl, Leu N Adrian, Chen Dannee, McLaughlin K John, Pehrson John R

Abstract excerpt

macroH2A histone variants have been implicated to function in gene silencing by several studies, including ones showing a preferential association of macroH2A on the inactive X chromosome. To examine macroH2A function in vivo, we knocked out macroH2A1. macroH2A1 knockout mice are viable and fertile. A broad screen of liver gene expression showed no evidence of defects in X inactivation but did identify genes that...

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Identifiers

PMID: 17242180
DOI: 10.1128/MCB.02334-06
PMCID: PMC1899912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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