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Article

Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome.

Biological psychiatry - 1 Jan 2021

Powell Samuel K, O'Shea Callan, Brennand Kristen J, Akbarian Schahram

Abstract excerpt

The heritability of common psychiatric disorders has motivated global efforts to identify risk-associated genetic variants and elucidate molecular pathways connecting DNA sequence to disease-associated brain dysfunction. The overrepresentation of risk variants among gene regulatory loci instead of protein-coding loci, however, poses a unique challenge in discerning which among the many thousands of variants...

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Identifiers

PMID: 33131715
DOI: 10.1016/j.biopsych.2020.06.033
PMCID: PMC7718420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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