Article

SnakeHichipTF reveals transcription factor logic underlying enhancer-promoter wiring in the human brain

2026-04-01

Abstract excerpt

Enhancer-promoter interactions are a central feature of gene regulation, yet the regulatory logic that governs their selective formation in complex tissues remains poorly understood. To address this gap, we developed SnakeHichipTF, a reproducible and scalable framework that integrates multi-engine HiChIP analysis with AI-based footprinting to decode the transcription factor (TF) logic underlying enhancer-promoter...

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Literature Corpus work: 23c0e945-0db0-5e63-811a-fd752b17a52f
DOI: 10.64898/2026.03.30.715320

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