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Article

Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer.

Cancer research - 15 Jan 2009

Hofer Matthias D, Kuefer Rainer, Maier Christiane, Herkommer Kathleen, Perner Sven, Demichelis Francesca, Paiss Thomas, Vogel Walter, Rubin Mark A, Hoegel Josef

Abstract excerpt

Fusion of the 5'-untranslated region of androgen-regulated TMPRSS2 promoter with ETS transcription factor family members is found frequently in prostate cancers, and recent work suggests that the most common TMPRSS2-ERG fusion is associated with an aggressive clinical phenotype compared with fusion-negative prostate cancer. Thus far, analysis of the fusion has been limited to sporadic cases of prostate cancer. In...

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Share to Chromosomes, Human, Pair 21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

Share to Neoplasm Staging

Share to Oncogene Proteins, Fusion

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Source

Identifiers

PMID: 19147579
DOI: 10.1158/0008-5472.CAN-08-2008

Genes

TMPRSS2
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer.PMID 19147579Read ↗

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TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signalingSemantic proximity Read ↗

Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status.Semantic proximity Read ↗

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.Semantic proximity Read ↗

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