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Article

Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2009

Luedeke Manuel, Linnert Carmen M, Hofer Matthias D, Surowy Harald M, Rinckleb Antje E, Hoegel Josef, Kuefer Rainer, Rubin Mark A, Vogel Walther, Maier Christiane

Abstract excerpt

The somatic fusion of TMPRSS2 to ETS oncogenes is a common event in prostate cancer (PCa). We hypothesized that defects in DNA repair may lead to an increase of chromosomal rearrangements and thus to the occurrence of ETS oncogene fusion. We have previously conducted a genome-wide linkage analysis in TMPRSS2-ERG fusion-positive PCa families, revealing potential susceptibility loci on chromosomes 5q14, 9q21,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19861517
DOI: 10.1158/1055-9965.EPI-09-0772

Genes

TMPRSS2
ERG
ESCO1
POLI
BRCA2
RMI1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes.PMID 19861517Read ↗

Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status.Semantic proximity Read ↗

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Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.Semantic proximity Read ↗

Extensive germline-somatic interplay drives prostate cancer through HNF1B co-option of TMPRSS2-ERGSemantic proximity Read ↗

Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERGSemantic proximity Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.Semantic proximity Read ↗

ETS fusion genes in prostate cancerSemantic proximity Read ↗

Multiple genomic alterations on 21q22 predict various <i>TMPRSS2/ERG</i> fusion transcripts in human prostate cancersSemantic proximity Read ↗

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