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Article

Hepatocytes Are the Principal Source of Circulating RBP4 in Mice.

Diabetes - 1 Jan 2017

Thompson Spencer J, Sargsyan Ashot, Lee Seung-Ah, Yuen Jason J, Cai Jinjin, Smalling Rana, Ghyselinck Norbert, Mark Manuel, Blaner William S, Graham Timothy E

Abstract excerpt

RBP4 is produced mainly by hepatocytes. In type 2 diabetes and obesity, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose intolerance. Observations that adipocyte RBP4 mRNA increases in parallel with circulating RBP4 in these conditions, whereas liver RBP4 mRNA does not, led to a widely held hypothesis that elevated circulating RBP4 is a direct result of increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27797907
DOI: 10.2337/db16-0286
PMCID: PMC5204311

Genes

RBP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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