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Article

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver

19 Feb 2021

Abstract excerpt

OBJECTIVE: Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 diabetes (T2D). We here examined in vivo effects of AAV8 (Adeno-Associated Viral vectors of serotype eight) GREM 1 targeting the liver in mature mice to increase its...

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PMID: 33606810
DOI: 10.1371/journal.pone.0247300

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