Article

Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion

2022-10-17

Abstract excerpt

Fatty acid binding protein 4 (FABP4) is a lipid chaperone secreted from adipocytes upon stimulation of lipolysis. Circulating FABP4 levels strongly correlate with body mass index and obesity-related pathologies in experimental models and humans. While adipocytes have been presumed to be the major source of hormonal FABP4, this question has not been addressed definitively in vivo . We generated mice with FABP4 del...

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Literature Corpus work: 5858a39d-a8c2-5774-a1c5-e0b664bfcf44
DOI: 10.1101/2022.10.13.511807

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