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Article

IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots.

Endocrinology - 1 Oct 2017

Maridas David E, DeMambro Victoria E, Le Phuong T, Mohan Subburaman, Rosen Clifford J

Abstract excerpt

Insulinlike growth factor (IGF) I induces adipogenesis in vitro. IGF-binding protein 4 (IGFBP4) is highly expressed in adipocytes and osteoblasts and is inhibitory of IGFs in vitro. We previously reported that Igfbp4 null mice (Igfbp4-/-) had decreased fat proportions at 8 and 16 weeks of age. However, the mechanism leading to the reduced adiposity remains unknown. The purpose of this study was to elucidate how...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28938423
DOI: 10.1210/en.2017-00248
PMCID: PMC5659704

Genes

IGFBP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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