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Article

Entry of Botulinum Neurotoxin Subtypes A1 and A2 into Neurons

18 Oct 2016

Abstract excerpt

ABSTRACT Botulinum neurotoxins (BoNTs) are the most toxic proteins for humans but also are common therapies for neurological diseases. BoNTs are dichain toxins, comprising an N-terminal catalytic domain (LC) disulfide bond linked to a C-terminal heavy chain (HC) which includes a translocation domain (H N ) and a receptor binding domain (H C ). Recently, the BoNT serotype A (BoNT/A) subtypes A1 and A2 were...

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PMID: 27795365
DOI: 10.1128/iai.00795-16

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