Article
Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2013
Meng Jianghui, Wang Jiafu, Lawrence Gary W, Dolly J Oliver
Abstract excerpt
Proteins responsible for basal and stimulated endocytosis in nerves containing small clear synaptic vesicles (SCSVs) or large dense-core vesicles (LDCVs) are revealed herein, using probes that exploit surface-exposed vesicle proteins as acceptors for internalization. Basal uptake of botulinum neurotoxins (BoNTs) by both SCSV-releasing cerebellar granule neurons (CGNs) and LDCV-enriched trigeminal ganglionic...
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